In a up to date learn about revealed in Vitamin, Metabolism, and Cardiovascular Illnesses, researchers examine the connection between nutritional polyphenol consumption and metabolic syndrome (MetS).

Find out about: Nutritional polyphenols, metabolic syndrome and cardiometabolic menace elements: An observational learn about in accordance with the DCH-NG subcohort. Symbol Credit score: Danijela Maksimovic/Shutterstock


Polyphenol-rich meals are related to cardiometabolic risk-lowering homes, with maximum research reporting the advantages of flavonoids, together with anthocyanins, flavonols, and flavan-3-ol categories. Despite the fact that polyphenols were widely researched within the context of MetS via bibliometric analyses, knowledge at the affiliation between ordinary polyphenol consumption and MetS are restricted.

Earlier research have reported that folks with larger polyphenol consumption have a decrease chance of growing MetS, higher waist circumference, blood power, and triglycerides (TG) ranges, decrease high-density lipoprotein ldl cholesterol (HDL-c) ranges amongst ladies, and increased fasting blood glucose ranges amongst women and men.

The PREDIMED-Plus learn about findings confirmed certain correlations between nutritional polyphenol consumption and HDL-c ranges; alternatively, there was once no affiliation between overall polyphenol intake and different metabolic illness traits.

In regards to the learn about

Within the provide observational learn about, researchers evaluation the cardiometabolic coverage conferred via nutritional polyphenols.

The learn about was once performed between August 2017 and January 2018 and comprised 676 Danish adults who participated within the Danish nutrition, most cancers, and health-next generations (DCH-NG-MAX) trial. Nutritional and scientific knowledge have been got the usage of on-line 24-hour nutritional recollects (24-HDRs) at baseline, six months, and 12 months.

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The net software was once connected to the nationwide meals database of Denmark and comprised 1,600 meals pieces. Different meals knowledge resources applied within the learn about incorporated the meals company of Sweden, the meals composition desk via McCance and Widdowson, and the myfood24 database. Secondary analyses have been carried out to evaluate variations within the associations via age, intercourse, smoking behavior, and scientific historical past.

Nutritional polyphenol consumption was once estimated the usage of the Phenol-Explorer database knowledge. General polyphenol consumption was once calculated via summing up the content material of esters, aglycones, and glycosides. Nutritional polyphenol consumption was once additionally estimated via category, together with phenolic acids, flavonoids, stilbenes, lignans, tyrosol, and alkylphenol.

Generalized linear blended modeling was once carried out to resolve the affiliation between nutritional polyphenol intake and cardiometabolic illness, and the percentages ratios (OR) have been made up our minds.

Knowledge have been basically got via chromatography, with changes made for gender and age, in addition to nutritional and way of life variables. Metabolic illness was once known the usage of the Global Diabetes Federation standards.

The DCH-NG MAX trial was once performed between August 2015 and April 2019 and comprised 39,554 adults, together with their organic kids, spouses, and grandchildren, representing the first-generation, first-generation-parents, and second-generation DCH learn about individuals, respectively.


The imply player age was once 44 years and the imply overall polyphenol consumption was once 1,368 mg/day, with 12% of people having MetS at baseline. Compared to Q1 (preliminary 3 months), MetS sufferers, the overall polyphenol, flavonoid, and phenolic acid consumption related to This autumn folks resulted in a 50% relief of their probability of growing metabolic illness.

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Larger intake of polyphenols, phenolic acids, and flavonoids was once associated with decrease ranges of HDL-c and systolic blood power (SBP). MetS incidence charges have been 12%, 9%, and 12% at baseline, six months, and 12 months, respectively. Moreover, MetS incidence charges ranged from 6% to fifteen% in quartiles of overall polyphenol intake and class-wise consumption.

Sensitivity analyses, which excluded folks with dangerous life and comorbidities, yielded equivalent findings. Of word, the statistically vital relationships for the overall polyphenol and phenolic acid consumption have been seen handiest amongst non-smokers. Consumption of flavonoid polyphenols, stilbene polyphenols, and tyrosol polyphenols correlated inversely with waist circumference measurements.

General polyphenol consumption confirmed an inverse affiliation with SBP and diastolic blood power (DBP) values. Effects have been maximum constant for the affiliation between the consumption of overall polyphenols, flavonoids, and phenolic acids and the chance of getting low HDL-c ranges; alternatively, alkylphenol consumption and coffee HDL-c have been definitely correlated. Best phenolic acid consumption was once associated with high-sensitivity C-reactive protein (hs-CRP) ranges.


Total, the learn about findings confirmed that larger intake of polyphenols, phenolic acids, and flavonoids decreased MetS dangers. The primary polyphenol category members have been phenolic acids and flavonoids at 63% and 32%, respectively, with proanthocyanidins and hydroxycinnamic acids maximum regularly fed on.

Magazine reference:

  • Lanuza, F., Zamora-Ros, R., Bondonno, N. P., et al. (2023). Nutritional polyphenols, metabolic syndrome and cardiometabolic menace elements: An observational learn about in accordance with the DCH-NG subcohort. Vitamin, Metabolism and Cardiovascular Illnesses. doi: 10.1016/j.numecd.2023.02.022

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